Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
Article Abstract:
The role of oxidized low-density lipoprotein (LDL) in the regulation of macrophage gene expression and in the pathogenesis of atherosclerosis was investigated. Human peripheral blood monocyte cultures and the human monocytic cell THP-1 were employed to evaluate the ability of oxidized LDL and PPARgamma ligands to induce monocytic differentiation. Results show that oxidized LDL can regulate the expression of macrophage genes through ligand activation of PPARgamma. These findings indicate that PPARgamma may play a key role in regulating foam cell gene expression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
Article Abstract:
High-fat feeding that induces hyperlipidemia and antherogenesis, stimulates the expression of both PGC-1 beta and sterol responsive element binding protein (SREBP)1c and 1a in liver is described. Unlike SREBP itself, PGC-1beta reduces fat accumulation in the liver while greatly increasing circulating triglycerides and cholesterol in VLDL particles.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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