PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization
Article Abstract:
A study was conducted to characterize PACS-1 as a member of a new gene family of cytosolic connector proteins needed for the localization of membrane proteins to the trans-Golgi network. Mouse embryo cDNA library was subcloned into pVP16 while DNA sequences were amplified by the polymerase chain reaction method. Results indicated that PACS-1 binds selectively to phosphorylated furin and supports multiple sorting systems.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Active and inactive protein kinases: structural basis for regulation
Article Abstract:
Protein kinases and phosphatases play an important role in cellular control and regulation. Some kinases require activation by phosphorylation and others do not. The activation segment of protein kinases and the control of its conformation via phosphorylation is governed by the sequence specificity of the kinase and the sequence in the activation segment that surrounds the phosphorylated residue.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Lingering mysteries of ubiquitin-chain assembly
Article Abstract:
The small protein ubiquitin is often linked to substrates as a polymer that vary in both linkage and length, which has important consequences for their function. In order to know the mechanisms of ubiquitin-chain assembly, deciphering them will shed light on why substrates differ in the extent and timing of polyubiquitin modification and how ancillary ubiquitination factors function.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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