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Structure and protein design of a human platelet function inhibitor

Article Abstract:

Platelet activation is inhibited through hematophagous arthropods that secrete a salivary apyrase by catabolizing ADP released from damaged tissues and blood cells. The human apyrase was redesigned using a comparative structural biology approach so as to enhance its ADPase activity by more than 100-fold.

Author: Liu, Jie, Lu, Min, Dai, Jiayin, Deng, Yigun, Smith Thomas M.

Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004

Blood platelets, Platelet activation, Blood cells

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Converting a motor to an anchor

Article Abstract:

Myosin VI moves along actin filaments to serve as a transport motor and it is also thought to anchor vesicles or proteins to actin. Load applied to myosin VI that can convert this motor from a transport to an anchor using single molecule observations is demonstrated.

Author: Miller, Kathryn G.

Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004

Actin, Myosin

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Subjects list: Analysis, Protein binding

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