PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis

Article Abstract:

The allele for platelet-derived growth factor A (PGDF-A) has been shown as homozygous lethal, producing pre- and post-natal lung defects in mouse embryos. PGDF-A has been suggested to induce the formation of alveolar myofibroblasts and associated elastin deposits. Suppression of PGDF-A suppresses the formation of progenitor alveolar myofibroblast cells. The PGDF family of genes control the embryonic development of cardiovascular, hematological and renal cells.

Genetic aspects, Gene expression, Lung diseases

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Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

Article Abstract:

Two mouse models are employed to study and analyze the effect of defective N-sulfation of heparan sulfate (HS) proteoglycans on the endothelical platelet-derived growth factor B (PDGF-B), used for pericyte recruitment during the vascular development. The results prove that appropriate N-sulfated domains and sufficient HS are very essential for pericyte recruitment, whereas the sequences of other sulfate residues do not play any important role in the reaction.

Science & research, Health aspects, Neovascularization, Proteoglycans, Sulfates, Clinical report

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