Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis
Article Abstract:
A study shows that sustained Notch activity is required for the temporal maintenance of specific cohorts of proliferating progenitors, which underlies the ability to specify late-arising cell lineages during pituitary organogenesis. It is learnt that sustained signaling in progenitor cells is required to prevent conversion of the late-arising cell lineages to early-born cell lineages, permitting specification of diverse cell types, a strategy likely to be widely used in mammalian organogenesis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Reconstructing MYC
Article Abstract:
The authors discusses the study of MYC, a member of molecular thugs hijacking cells. The topics of interest include the ability of MYC to operate at transcription cycle's later stages, and the ability of MYC network to cotranscript modifying the expression locally on an ad hoc basis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Cyclin-dependent kinase inhibitor, dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis
- Abstracts: A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization. Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating
- Abstracts: Cooperation between C/EBP(alpha) TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation
- Abstracts: Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays