PML is induced by oncogenic ras and promotes premature senescence

Article Abstract:

Promyelocytic leukemia (PML), which promotes premature aging, is brought on by oncogenic ras. Gene expression patterns have been compared to look at ras-arrested vs quiescent IMR90 fibroblasts. A gene up-regulated in ras-induced arrest was PML protein. It is a potential tumor suppressor and encodes a component of nuclear structure, promyelocytic oncogenic domains. Results show that PML acts with Rb and p53 to promote ras-induced senescence.

United States, Statistical Data Included, Physiological aspects, Cytochemistry, Fibroblasts, Ras genes, Old age

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Dissecting eIF4E action in tumorigenesis

Article Abstract:

A study is presented to show that the ocogenic activity of eIF4E correlates with its ability to activate translation and become phosphorylated on Ser 209. The results show how eIF4E contributes to tumorigenesis and how it is suitable for therapeutic intervention.

Science & research, Phosphorylation, Genetic translation, Translation (Genetics), Apoptosis

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E1A signaling to p53 involves the p19ARF tumor suppressor

Article Abstract:

Via a signaling pathway that involves the tumor suppressor p19ARF and retinoblastoma protein, the adenovirus E1A oncogene activates p53. It can be seen that p19 is part of a p53-dependent failsafe system to stop rampant cell proliferation. There are synergistic effects for p19ARF and DNA damage pathways in inducing p53 and they may help E1A's contribution to chemo- and radiosensitivity.

DNA damage, Tumor suppressor genes, Cell proliferation, Adenoviruses

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