Phenotypic and molecular characterization of SerD, a dominant allele of the Drosophila gene Serrate

Article Abstract:

Investigation of SerD, a dominant allele of the Drosophila gene Serrate, phenotypically and at the molecular level, reveals that incorporation of a retrotransposon in the 3' untranslated region of the gene is responsible for the mutation. This mutation increases the stability of Ser RNA and facilitates the production of more proteins. Longer half-life of the RNA facilitates the identification of serrate protein in the edge zone of the wing margin in third instar larvae. Expression of the Serrate protein inhibits the development of the wing margin.

Research, Membrane proteins

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Seven genes of the enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins

Article Abstract:

Seven genes in Drosophila melanogaster's enhancer of split complex encode proteins with a configuration of helix-loop-helix (HLH). Three of these genes have been reported previously and the other four have been studied only recently. Transcription patterns of the seven genes are nearly identical. The protein product of these genes are required in the differentiation of neuroepidermal cells into neural and epidermal progenies in early neurogenesis.

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The enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells

Article Abstract:

Seven related genes in the enhancer split complex in chromosome 3 of Drosophila melanogaster are required at the onset of differentiation of neuroectodermal cells into neural and epidermal progenitors. These genes codes for highly conserved DNA-binding protein belonging to a class of proteins known as bHLH. Limited redundancy of these genes enable their products to partially replace each other. Other unrelated genes are found within the complex.

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