Plasmodium's sticky fingers
Article Abstract:
The life cycle of the malaria parasite (plasmodium) is very complex as they engage in highly specific and varied interactions with cell types of both the mammalian host and the mosquito vector. A detailed molecular insight into an intimate interaction between a malaria parasite protein and its host cell receptor that enable the parasite to invade erythrocytes is reported.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum
Article Abstract:
The crystal structure of the erythrocyte binding domain of EBA-175, RII, which is established as a vaccine candidate is presented. An insight into the mechanism of erythrocyte invasion by the malarial parasite is presented which aid in rational drug design and vaccines.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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A central role for P48/45 in malaria parasite male gamete fertility
Article Abstract:
Results show that the surface protein PFS48/45 of male gametes of Plasmodium falciparum mediates fertilization process as evidenced by mutant male gamete's inability to penetrate fertile female gametes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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