Polybromo protein BAF180 functions in mammalian cardiac chamber maturation
Article Abstract:
The ablation of the mammalian chromatin remodeling complex, PBAF-specific subunit BAF180 in mouse embryos results in severe hypoplastic ventricle development and trophoblast placental defects, similar to those found in mice lacking nuclear receptors, RXRalpha and PPARgama. Embryonic aggregation analyses reveal that in contrast to PPARgama-deficient mice, the heart defects are likely result of BAF180 ablation, rather than an indirect consequence of trophoblast placental defects.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Coactivator cross-talk specifies transcriptional output
Article Abstract:
The cell uses several classes of regulatory coactivator complexes including two central players, TFIID and Mediator (MED), in potentiating activated transcription. Robust response of the metallothionein genes to heavy metal is exploited as a model for transcriptional activation by analyzing direct factor recruitment in both heterogeneous cell populations and at the single level.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator
Article Abstract:
A stable complex containing the Evf-2 ncRNA and the Dlx-protein forms in vivo, suggesting that the Evf-2 ncRNA activates transcriptional activity by directly influencing Dlx-2 activity. These experiments identify a novel mechanism whereby transcription is controlled by the cooperative actions of an ncRNA and a homeodomain protein.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Telomerase RNA function in recombinant Tetrahymena telomerase. Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein association
- Abstracts: The Homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Homeobox galore: When reproduction goes RHOX and Roll
- Abstracts: Heterochromatin-many flavors, common themes. The paradox of functional heterochromatin. The ovotestis: An underdeveloped organ of evolution
- Abstracts: The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation