The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation
Article Abstract:
The relationship between nuclear localization and transcriptional activity of the endogenous murine beta-globin locus during erythroid differentiation was examined. The results suggested that the locus control region (LCR)-dependent association of the beta-globin locus with transcriptionally engaged polymerase II foci provided the driving force for relocalization of the locus toward the nuclear interior during erythroid maturation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Form follows function: the genomic organization of cellular differentiation
Article Abstract:
Studies have indicated that the linear arrangement of genes within eukaryotic genomes is nonrandom. It is suggested that determining the relationship between organization and the linear arrangement of genes would lead to a greater understanding of how transcriptomes, dedicated to a particular function or fate, are coordinately regulated.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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- Abstracts: An initial blueprint for myogenic differentiation. Switching of the core transcription machinery during myogenesis
- Abstracts: Constricting restricted transcription: The (actively?) shrinking web. The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation