Polycystins: from mechanosensation to gene regulation
Article Abstract:
A study is conducted to understand the role of polycystin proteins in human diseases. It is suggested that polycystin proteins form mechanosensory transduction complexes involved in a variety of biological functions including sperm fertilization, mating behavior, and asymmetric gene expression in different species, hence the pros and cons of their candidacy as mechanically gated channels are discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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Blurring cis and trans in gene regulation
Article Abstract:
An attempt is made to explain the long-standing enigma of the choice of odorant receptor (OR) gene expression by olfactory neurons, which interacts with multiple OR gene promoters on different chromosomes. It is suggested that a mechanism allows olfactory sensory neurons to choose randomly and express only one out of more that 1000 OR genes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Alternative slicing regulation impacts heart development
Article Abstract:
SR proteins serve multiple roles in the posttranscriptional control of gene expression, including as regulators of alternative splicing. It is demonstrated that a heart-specific knockout of one SR protein, ASF/SF2, produces cardiomyopathy and misregulation of specific alternative splicing events during early postnatal development.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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