Polypeptide translocation: a pretty picture is worth a thousand words
Article Abstract:
The demonstration of a pore formed by the assembly of Sec61p complexes in detergent solution and in liposomes consolidates two major areas in polypeptide translocation research, which have witnessed developments in recent years. These are the isolation of the membrane proteins which play a role in polypeptide transit and the detection of channel activity significant to translocation. These two major themes resulted from the development of several biochemical, genetic and biophysical approaches to identify the elements of the translocation event and to examine the environment of the putative channel in the ER membrane.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis
Article Abstract:
A balanced and herited translocation in a family with autosomal dominant supravalvular aortic stenosis (SVAS) is revealed to impair the elastin gene and cosegregate with the disease in this family. Thus, the notion that mutations in the elastin gene cause SVAS is made even more relevant. These findings are obtained from pulse-field gel, Southern and DNA sequence analyses, and are confirmed by applying restriction enzymes that cut human genomic DNA more frequently. In addition, some of the pathological properties of SVAS are found to be present in atherosclerotic vessels.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Protein translocation across mitochondrial membranes: what a long, strange trip it is
Article Abstract:
Protein precursors move across mitochondrial membranes by binding to receptors on the outer and inner membranes (OM and IM), and then pass through the membrane translocation channels. The mitochondrial stimulation factor targets the precursors to the receptors and breaks up precursor aggregates. The IM vesicles translocate the precursors into their lumen while the OM vesicles fail to to do so. The complete translocation of precursors into the mitochondrial lumen requires an interaction between the OM and IM vesicles.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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