Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells

Article Abstract:

Research has been conducted on the neural crest stem cells (NCSCs). The ability of the Notch ligands to inhibit neurogenesis in NCSCs is discussed.

United States, Statistical Data Included, Analysis, Neural crest, Developmental neurology, Cell research, Cytological research, Ligands, Ligands (Chemistry)

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Regulatory mechanisms in stem cell biology

Article Abstract:

Stem cells have basic common properties that are true across diverse species, tissues and developmental stages, namely, the capacity for self-renewal and differentiation. Stem cells also share common molecular mechanisms which underlie these properties. The expression of telomerase, for instance, is the mechanism that regulates stem cell self-renewal capacity. Some stem cells, on the other hand, can be directed to choose one pathway of differentiation by growth factors, while stem cells in other systems may make the choice stochastically. In the latter case, growth factors may function primarily as survival factors or mitogens for committed cells.

Cellular control mechanisms, Cell regulation, Cell metabolism

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Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells

Article Abstract:

Neural crest stem cells (NCRCs) were isolated from mammalian fetal peripheral nerve using flow cytometry and cell surface markers. These cells were found to be functionally and phenotypically undistinguishable from NCSCs isolated by culturing embryonic neural tube explants. Results show that neural stem cells persist in the fetal peripheral nerve by undergoing self-renewal. This demonstrated persistence of NCRCs is important as it provides fresh insight into the etiology of certain cancers associated with the peripheral nervous system.

Cancer research, Flow cytometry, Cancer, Cell surface antigens, Neural circuitry, Fetal tissues, Nerves, Peripheral, Peripheral nerves

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