Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus
Article Abstract:
A pathway for chromatin opening and transcriptional activation of the human beta-globin locus has been investigated relative to nuclear localization and histone acetylation. Mechanism, structural correlates and cis-acting elements were studied. A multistep model seems to exist for gene activation. Localization away from centromeric heterochromatin is necessary to achieve general hyperacetylation and open chromatin structure for the locus.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher erkaryote
Article Abstract:
A genome-wide chromatin structure analysis in a higher eukaryote is performed to understand the interplay between various histone modifications, including acetylation and methylation. It is found that a binary pattern of histone modifications among euchromatic genes, with active genes being hyperacetylated for H3 and H4 and hypermethylated at Lys 4 and Lys 79 of H3, and inactive genes being hypomethylated and deacetylated at the same residues.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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A functional enhancer suppresses silencing of a transgene and prevents its localiztion close to centromeric heterochromatin
Article Abstract:
Ability of an enhancer and derivative mutants to suppress silencing of a transgene has been studied to investigate mechanisms by which enhancers maintain gene expression in repressive chromatin environments. The method controlled for position effects. Findings showed ability of an enhancer to suppress silencing depends on integrity of core enhancer motifs. Transcriptional enhancer may maintain expression by preventing localization of a gene near centromeric heterochromatin. They may act by recruiting a gene to a nuclear compartment where transcription is favored and stably heritable.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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