Functional discovery via a compendium of expression profiles
Article Abstract:
One assay can be used to monitor hundreds of cellular functions at the same time. A reference database, a compendium of expression profiles, corresponding to 300 different mutations and chemical treatments in S. cerevisiae has been put together. The cellular pathways affected can be found by pattern matching even when profiles are very subtle.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology
Article Abstract:
A challenge for bioinformatics and post-genome biology brought by research into protein diversity from alternative splicing is discussed in this minireview article. Splicing analysis can be seen as a fine brush on the genome. A global view of splicing regulation is needed for a picture of the total complement of proteins of an organism, and it must be combined with detailed understanding of its mechanisms if understanding of how the complement changes with development/environment is to be gained.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
The rde-1 gene, RNA interference, and transposon silencing in C. elegans
Article Abstract:
The mechanism of RNAi and the possibility that a natural function of RNAi is transposon silencing are discussed. The identification of RNA interference-deficient (rde) mutants in Caenorhabditis elegans (nematodes) is discussed. C. elegans mutants resistant to double-stranded RNA (dsRNA)-mediated interference (RNAi) were used to study the interference process.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Secondary structure of vertebrate telomerase RNA
- Abstracts: Products from the incomplete metabolism of pyrene by polycyclic aromatic hydrocarbon-degrading bacteria. Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase as a biocatalyst
- Abstracts: A nonproteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phase
- Abstracts: Isolation and characterization of five Erwinia amylovora bacteriophages and assessment of phage resistance in strains of Erwinia amylovora
- Abstracts: Growth characteristics and itraspecies host specificity of a large virus infecting the dinoflagellate Heterocapsa circularisquama