Quantitative genetic variation in body size of mice from new mutations

Article Abstract:

The amount of genetic variance per generation in the 6-week body weight of inbred mice was measured through 25 generations. The genetic components of variance were estimated using a restricted maximum likelihood analysis on an animal model having additive genes of small effects. The analysis showed that heritability for body size increased by 1.0% per generation. Ten percent of the variance was attributed to environmental effects, while 0.3% of the increase in heritability was attributed to spontaneous mutation. This value for the mutation component is higher than previous estimates on Drosophila, but similar to the estimates in the skeletal traits of mice.

Analysis, Mice, Mice (Rodents), Variation (Biology), Quantitative genetics

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Average dominance for polygenes: drawbacks of regression estimates

Article Abstract:

The validity of estimates for the average dominance of genes controlling fitness characteristics is affected by the wrong use of regression methods. Biases result which are either errors of estimation on homozygous effects or errors arising from the combination of widely differing mutation effects. The first error forces the regression slope to take on a recessive trait. The second error is compounded if mutants being combined are recessive.

Genetic regulation

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Polygenic mutation in Drosophila melanogaster: non-linear divergence among unselected strains

Article Abstract:

The polygenic mutation in Drosophila melanogaster is investigated by developing an autoregressive model which fits to the line of variance. The investigation reveals that the variance between the sternopleural bristle number and abdominal lines increases only after 100 generations, which are subjected to inbreeding. The autoregressive model also indicates the presence of the phenomena of strong natural selection.

Drosophila

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