RIGUI, a putative mammalian ortholog of the Drosophila period gene

Article Abstract:

All living organisms are controlled by circadian rhythms fuelled by endogenous oscillators. The molecular components of mammalian circadian clocks remain elusive. A human gene termed RIGUI, encoding a bHLH/PAS protein which is 44% homologous to Drosophila period has been isolated. The mouse homolog (m-rigui) is presented in a circadian pattern in the suprachiasmatic nucleus (SCN), the mammal circadian clock regulator. Expression patterns indicated that RIGUI is a mammalian ortholog of the Drosophila period gene.

Human genetics, Gene expression

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A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light

Article Abstract:

Mper1, a mouse gene, exhibiting the properties expected of the circadian clock gene, has been reported. It is expressed in the suprachiasmatic nucleus (SCN) in a circadian pattern, and maintains the pattern in constant darkness. A second mammalian gene, mper2 has been isolated, with the same properties and increased homology to Drosophila period.

Cell research, Cytological research

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Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock

Article Abstract:

Results point out that heme biosynthesis enzymes are regulated by mPer1 and mPer2 encoded proteins, which individually and complemetnarily exhibit influence on the manifestation of circadian rhythms in mice.

United States, Analysis, Physiological aspects, Gene mutations, Gene mutation, Genetic aspects, Enzymes, Physiological regulation, Biological control systems, Enzyme synthesis

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