RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers
Article Abstract:
A study used SILAC, a quantitative mass spectrometry-based method, to identify and quantify proteins interacting in an attachment-dependent manner with focal adhesion proteins. Results reveal the existence of spreading initiation centers (SIC), as distinct from focal adhesions, that demonstrate the role for RNA and RNA binding proteins in the initiation of cell spreading.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Proteome analysis of separated male and female gametocytes reveals novel sex-specific plasmodium biology
Article Abstract:
Gametocytes, the precursor cells of malaria-parasite gametes, circulate in the blood and are responsible for transmission for host to mosquito vector. Of all the malaria life cycles stages analyzed the male gametocyte has the most distinct proteome, containing many proteins involved in flagellar-based motility and rapid genome replication.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
Article Abstract:
A general mass spectrometric technology is developed and applied for identification and quantitation of phosphorylation sites as a function of stimulus, time and subcellar location. The dynamic phosphoproteome has provided a missing link in a global, integrative view of cellular regulation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C. elegans. The Fanconi road to cancer
- Abstracts: Rotavirus virus-like particles as surrogates in environmental persistence and inactivation studies
- Abstracts: RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination
- Abstracts: Structural basis for cooperativity in recruitment of MAML coactivators to notch transcription complexes. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the Avian Genome: insights into human chagas disease
- Abstracts: A DNA integrity network in the yeast Saccharomyces cerevisiae. Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast.