RNAi components are required for nuclear clustering of Polycomb group response elements
Article Abstract:
Components of the RNA interference (RNAi) machinery are involved in the production of small RNAs at transgenic Fab-7 copies. Dicer-2, PIWI, and Argonaute1, three RNAi components, frequently colocalize with Drosophila Polycomb group bodies and their mutation significantly reduces the frequency of PcG-dependent chromosomal associations of endogenous homeotic genes, suggesting a novel role for the RNAi machinery in regulating the nuclear organization of PcG chromatin targets.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Polycomb group-dependent Cyclin A repression in Drosophila
Article Abstract:
A study is conducted to find out whether Drosophila cell cycle genes are directly regulated by polycomb group (PcG) proteins through PcG response elements (PREs). The results show that Cyclin A is directly regulated by PcG proteins, linking them to cell cycle control in vivo.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Inheritance of polycomb-dependent chromosomal interactions in Drosophila
Article Abstract:
Results indicate that the cellular memory module regulating the homeotic gene Abdominal-B in Drosophila, Fab-7, can mediate long-distance interchromosomal interactions, which are heritable through mitotic and meiotic cell division.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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