RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans

Article Abstract:

The tethering of a mammalian arginie-serine-rich (RS) domain to a yeast actin pre-mRNA rescues splicing of certain branchpoint or 5' splice site mutants in which U snRNA base-pairing was decreased. It is found that in the absence of other splicing factors an RS domain tethered to a pre-mRNA selectively contacts a double-stranded RNA region and enhances RNA-RNA base-pairing.

Genetic aspects, Mammals, Messenger RNA, Yeast fungi, Yeasts (Fungi), Genetic research, Small nuclear ribonucleoproteins

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In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer

Article Abstract:

Interaction of Gal4-Tral is found essential for recruitment of SAGA (Spt/Ada/Gen5/acetyltransferase) to the upstream activating sequence (UAS) and SAGA in turn recruits the Mediator complex to the UAS. Studies reflect the process of transcriptional stimulation via activator-target interaction.

Genetic transcription, Transcription (Genetics)

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The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53

Article Abstract:

The chicken anemia virus protein Apoptin can induce apoptosis in a variety of human malignant cell lines. The research confirms the ability of Apoptin to induce apoptosis in the absence of p53 and recommend that the APC/C is a novel target for anticancer drug development.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Anticancer Drugs, Chemotherapeutic Drugs, Anticancer Immunostimulant Preps, Antineoplastic agents, Dosage and administration, Cell lines, Apoptosis, Antimitotic agents

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