Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
Article Abstract:
The role of the serine/threonine protein kinase Atk signaling pathway in the development of physiological hypertrophy, pathological hypertrophy and heart failure is examined, along with the regulation of cardiac growth, contractile function, and coronary angiogenesis. The downstream substrates of Atk that mediates its positive inotropic or cardioprotective effects have provided vital clues for the development of novel therapeutic strategies for heart diseases.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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The Ski oncoprotein interacts with the Smad proteins to repress TGF beta signaling
Article Abstract:
The Ski nuclear oncoprotein, which interacts with the Smad proteins to repress transforming growth factor (TGF)-beta signaling, is discussed. Recent studies suggest a new paradigm for inactivation of the Smad proteins, which are critical signal transducers downstream of the receptors of the TGF-beta superfamily, by an oncoprotein through transcriptional repression. Smad2, Smad3 and Smad4 associate with Ski through their MH2 domains.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Identification of phosphatases for Smad in the BMP/DPP pathway
Article Abstract:
Biochemical and genetic evidence suggest that pyruvate dehydrogenase phosphates (PDP) directly dephosphorylates Mothers against Decapentaplegic and inhibits signal transduction of Decapentaplegic (DPP). It is shown that the mammalian PDP's are important in dehphosphorylation of bone morphogenetic protein (BMP)-activated Smad1 but not TGF-beta-activated Smad2 and Smad3.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
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