The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis
Article Abstract:
The ATM-related domain of TRRAP has been found to be necessary for Myc-dependent oncogenesis and histone acetyltransferase (HAT) recruitment. To look at the function of the ATM-related region of TRRAP, a progressive series of C-terminal deletions has been made from a FLAG epitope-tagged full-length TRRAP cDNA expression vector.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Regulation of cyclin D2 gene expression by the Mrc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter
Article Abstract:
Regulation of cyclin D2 gene expression is discussed. Myc has been found to be bound to the cyclin D2 promoter in vivo. Recruitment of TRRAP and regulation of histone acetylation are vital for transcriptional activation by Myc.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails
Article Abstract:
Transcription regulation by histone methylation is discussed in this review article with attention to the interplay of various covalent modifications of the core histone tails. These tails are susceptible to phosphorylation, acetylation, ubiquitination and methylation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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