Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

Article Abstract:

New research has shown that Rel-NF-kappaB physiologically regulates expression of a Bcl-2-like protein that is critical for the control of cell survival during lymphocyte activation. In normal B and T cells, it was found that expression of the Bcl-2 prosurvival homolog, A1 is quickly induced in a Rel-dependent way by mitogens. In B-cell lines from c-rel-/- mice, which are subject to apoptosis as a result of antigen receptor ligation, constitutive expression of an A1 transgene takes away that pathway to cell death.

Australia, Causes of, Observations, Cell death, Antigen receptors, T cell, T cell antigen receptors, Genetic transcription, Transcription (Genetics), B cells, Cell differentiation, Mitogens, Lymphocytes

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A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation

Article Abstract:

A study reveals that 46 unique residues within an 86-residue segment of the Rel homology region of c-Rel are responsible for the c-Rel requirement for Il12b gene induction by lipopolysaccharide in bone marrow-derived macrophages. The unique functions of closely related transcription factor family members can be dictated by difference in the range of DNA sequences recognized at high affinity, despite having similar binding site consensus sequences and DNA contact residues.

Genetic aspects, Macrophages, Bone marrow

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Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response

Article Abstract:

The functional roles of SWI/SNF and Mi-2beta complexes during gene activation in macrophages in response to lipopolysaccharide (LPS) stimulation were studied using retroviral RNAi strategy. The results suggested that the ATP-dependent nucleosome remodeling complexes might be attractive targets for modulating the strength of an inflammatory response or other inducible responses.

Chromatin, Cytokines, Chemical properties

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