Synapse-specific and neuregulin-induced transcription require an Ets site that binds GABP alpha/GABP beta

Article Abstract:

Neuregulin (NRG)-induced and synapse-specific transcription must have an Ets site that can bind GABP alpha/GABP beta. By transfection of some gene fusions into a muscle cell line it has been shown that a potential binding site for Ets proteins is necessary for NRG-induced gene expression. An NRG-response element (NRE) has been shown to be required for synapse-specific transcription in mice. GABP alpha is an Ets protein and GABP beta is a protein that has no Ets domain, but does dimerize with GABP alpha. It seems that GABP alpha/GABP beta mediates transcriptional response of the acetylcholine receptor (AchR) delta-subunit gene to synaptic signals.

Observations, Genetic regulation, Genetic transcription, Transcription (Genetics), Protein binding, Acetylcholine, Acetylcholine receptors

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Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle

Article Abstract:

Runx1 is required to sustain muscle by preventing denervated myofibers from undergoing myofibrillar disorganization and autophagy, structural defects found in a variety of congenital myopathies. The findings indicate that only 29 genes, encoding ion channels, signaling molecules, and muscle structural proteins, depend upon Runx1 expression, suggesting that their misregulation causes the dramatic muscle wasting.

Analysis, Prevention, Hematopoiesis, Acute myelocytic leukemia, Atrophy, Muscular, Muscular atrophy, Denervation

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The formation of neuromuscular synapses

Article Abstract:

Synapses are formed by a series of steps starting from the generation of neurons. The postsynaptic differentiation is induced following the movement of axons to their skeletal muscle cells. There is also the step when presynaptic terminal and postsynaptic membrane are induced. Current knowledge of neuromuscular synapses formation is based on studies of vertebrates.

Research

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