Remembering Eva Neer
Article Abstract:
The life, career and accomplishments of Eva Neer, born in Poland and eventually becoming mother of two and a Harvard professor of biochemistry, are reviewed by a fellow heart researcher. Her work led to acceptance of the fact that G(sub.beta)(sub.gamma) activates as many effectors as does G(sub.alpha). She was an honest and courageous woman in the crusade to have this work accepted and she worked surveying the career paths of women at Harvard Medical School, fighting to make that environment more fair. She was fun to be with, as well.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Calcium signaling
Article Abstract:
Ionized calcium (Ca2+) forms the commonest signal transduction unit in cells and cytosolic Ca2+ level buffering leads to specialized Ca2+-binding domains in proteins. Incorporation of the binding domains into many proteins facilitates the action of Ca2+ as a triggering second-messenger element that activates effector molecules to undergo conformational changes. Depolarization of membrane potential regulates the action of Ca2+ as a signal transduction unit.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Symmetry, selectivity, and the 2003 Nobel Prize
Article Abstract:
This essay describes the discovery and elaboraion of ion channels in biological membranes and how each of the component regulate ions and water across the membranes via ion- and water channels based on symmetry and selectivity. The research was awarded the 2003 Nobel Prize to Rod MacKinnon and Peter Agre.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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