Replication arrest
Article Abstract:
Bacterial chromosomal replication forks help synthesize DNA from template information. Arrest of the replication forks is caused by terminator protein-binding sites at the ends of Escherichia coli and Bacillus subtilis. The termination systems of the two bacteria, Ter-Tus complex in E. coli and IR-RTP in B. subtilis, have some common features that may form the basis of the replication termination mechanism. Entry of the replication forks is stopped in one direction at the edge of the DNA site, where the termination proteins establish asymmetric contact. The opposing fork reaches the initial fork at this site, resulting in termination.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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The transactivator proteins VP16 and GAL4 bind replication factor A
Article Abstract:
The acidic activation domains of the transcription factors VP16, GAL4 and p53 bind directly and selectively to the largest subunit of the trimeric RPA complex of human and yeast replication factor A (RPA). The binding of VP16 (virion protein) to RPA is aided by the reduced ability of GAL4-VP16 to activate polyomavirus DNA replication. The initiation of DNA replication is normally stimulated by the activation of the C-terminal domain of VP16. Also, transcription factors may stimulate DNA replication, and cause viral T antigen and RPA to recruit DNA polymerase alpha to the preinitiation complex.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Archaea and the origin(s) of DNA replication proteins
Article Abstract:
A study was conducted on archaea and the origins of DNA replication proteins. Archaea, an organism having circular chromosomes where genes are tightly arranged, contains genomes which are seemingly bacterial in character. Features of bacterial replicative DNA polymerases confirm that archaea looks like bacteria in terms of replication proteins but only in limited sequences. This is due to the fact that the cenancestor do not contain a DNA genome but a single based RNA.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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