Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
Article Abstract:
Research was conducted to study the functions of phosphatases in hippocampal-dependent memory. Barnes maze experiments were carried out wherein rats were evaluated on the novel object recognition task. Mice were also injected with pentobarbital and decapitated. Results showed that rats that expressed a form of calcineurin were characterized by a specific memory defect on the spatial version of the Barnes maze. They also indicated that calcineurin activity increases in the hippocampus resulted to a defect in the transition phase.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin
Article Abstract:
A research was conducted to examine the function of phosphatases in synaptic plasticity by using genetic techniques. A deletion mutant of the catalytic subunit Aalpha of murine calcineurin was determined to increase calcineurin levels in the forebrain of rats. Results showed that calcineurin overexpression was primarily limited to the hippocampus in CN98 mutant mice. Moreover, they also suggested that synaptic transmissions were not modified by the overexpression of enzymes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin
Article Abstract:
Research has been conducted on the hippocampal-dependent synaptic plasticity and memory storage threshold affected by the balance between protein phosphorylation and deposphorylation dependent on phosphatase calcineurin. The effect of genetically inhibiting calcineurin on the plasticity and memory has been investigated and the results are presented.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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