SARs are cis DNA elements of chromosome dynamics: synthesis of a SAR repressor protein
Article Abstract:
The chromosomal scaffold-associated regions (SARs) control the condensation and shape of chromosomes. Multi-AT hook (MATH) proteins bind to the AT-rich regions of the SARs causing defective condensation and restructuring of Xenopus chromosomes. In the presence of MATH proteins, chromatin condenses like the wild-type chromatin but fails to assemble into chromosomes. MATH proteins added to mitotic chromosomes restructure the chromosomes into chromatid balls. The effect of the MATH proteins is due to direct interaction with the SARs.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Condensins, cohesins, and chromosome architecture: how to make and break a mitotic chromosome
Article Abstract:
Model organisms are used for studying chromosomal activities more efficiently. With the use of models, identification of important factors which contribute to the condensation and segregation of mitotic chromosomes were studied. Structural Maintenance of Chromosomes (SMC) proteins play an important role for building and breaking the cell cycle. Topoisomerase II contributes to disentanglement of chromosomes while MCD1 prevents mitotic cell replication through its functional mitotic checkpoint control.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Identification and characterization of a bacterial chromosome partitioning site
Article Abstract:
Research was conducted to characterize a DNA site associated with the chromosome partitioning in Bacillus subtilis. B. subtilis strains that contained the trpC and pheA mutations were derived from AG174 while double crossover technique transformation was utilized to introduce mutations into the chromosome. Results revealed a family of chromosome partitioning sites from B. subtilis and showed that the presence of a single site on stabilized the plasmid.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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