Protein tyrosine phosphatases in the human genome
Article Abstract:
Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. The set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families is presented. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease are discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Indicted: Worms caught using steroids
Article Abstract:
Detailed genetic studies that provide new insights into endocrinology in the nematode worm Caenorhabditis elegans are previewed. The findings identify natural steroid ligands for the DAF-12 nuclear receptor, clarify that endocrine circuits regulate progression through the life cycle and aging in all higher organism from C. elegans up to human.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: From form to function: signaling by protein tyrosine phosphatases. Redox Redux: Revisiting PTPs and the control of cell signaling
- Abstracts: Succession and regulation factors of small eukaryote community composition in a lacustrine ecosystem (Lake Pavin)
- Abstracts: Natural transformation-mediated transfer of erythromycin resistance in Campylobacter coli strains from turkeys and swine
- Abstracts: Nascent peptide-mediated translation elongation arrest coupled with mRNA degradation in the CGS1 gene of Arabidopsis
- Abstracts: Transcriptone of a Nitrosomonas europaea mutant with a disrupted nitrite reductase gene (nirK). Cellular response of Shewanella oneidensis to strontium stress