Select Listeria monocytogenes subtypes commonly found in foods carry distinct nonsense mutations in inlA, leading to expression of truncated and secreted internalin A, and are associated with a reduced invasion phenotype for human intestinal epithelial cells
Article Abstract:
The identification of additional mutations leading to premature stop codons (PMSCs) in internalin (InlA) by using Listeria monocytogenes isolates, the prevalence of Listeria monocytogenes isolates harboring InlA PMSC mutations among human, animal and food-source populations in the US and the determination of the invasion phenotypes of Listeria monocytogenes strains with and without InlA PMSCs are reported. The results have shown that specific Listeria monocytogenes subtypes that are common among the US food isolates but rare among human listeriosis isolates carry InlA mutations that are associated with an attenuated invasion phenotype.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2005
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Multilocus sequence typing supports the hypothesis that cow- and human-associated Salmonella isolates represent distinct and overlapping populations
Article Abstract:
Serotyping and a multilocus sequence typing (MLST) scheme, based on the sequencing of three genes (fimA, manB, and mdh), are used to characterize the human and bovine clinical Salmonella isolates obtained from across New York state over the course of 1 year. The results have shown that cattle might be a reservoir for many of the common human disease-associated serotypes and sequence type (ST) that are not associated with avian hosts.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2006
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Ecology and transmission of Listeria monocytogenes infecting ruminants and in the farm environment
Article Abstract:
The comprehensive datasets on the prevalence and subtype composition of Listeria monocytogenes in ruminant feces, animal feeds and the farm environment were collected by using a case-control study design. These findings provide an insight into L. monocytogenes transmission in ruminant farming systems, which allows better control of listeriosis in animals and reduces foodborne listeriosis in humans.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2004
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