Sense from nonsense: RNA editing in mitochondria of kinetoplastid protozoa and slime molds
Article Abstract:
Guide RNAs (gRNAs) in the genome of the trypanosomatid species of the kinetoplastid protozoa form editing domains in which the down stream editing forms upstream anchor sequences. The process of editing in the cryptobiid species, Trypanoplasma borreli, occurs by a similar mechanism. The point of editing is identified by the mismatch between the gRNA and the edited mRNA but the mechanism of the removal and addition of U's is not known. In Physarum, the editing is precise and efficient but the mechanism of the insertion and substitution involved in the editing process is not known.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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The yeast splice site revisited: new exon consensus from genomic analysis
Article Abstract:
An analysis of the entire Saccharomyces cerevisiae genome through the creation of the intron/exon subdatabase revealed significant conservation of nucleotides at positions -2, -3 and -4 at the 5' end of exons. This nucleotides are postulated to interact with a small nuclear RNA (snRNA) that is involved in the splicing process. One of these snRNAs is U5 and random pairing revealed that U5 undergo partial pairing at the 5' end of exons via the nucleotides at positions -2, -3 and -4.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
Article Abstract:
Research was conducted to test whether the HIV-1 Tat protein regulates C-related protein-CDK9 to RNA polymerase II through cooperative binding to transactivation response (TAR) element RNA. An antigen was utilized to produce polyclonal antibodies specific to cyclin T while TAR-1 RNAs were synthesized by T7 RNA polymerase. Results indicated that HIV-1 TAR RNA elements evolved to determine Tat when bound to cyclin T in a complex, rather than free Tat alone.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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