Serpentine cAMP receptors may act through a G protein-independent pathway to induce postaggregative development in dictyostelium
Article Abstract:
Activation of the transcription factor G box-binding factor (GBF) gene requires exogenous cAMP signaling pathway to initiate the expression of postaggregative or cell type-specific genes. Expression of GBF is induced by cAMP through cell surface receptors. At high cAMP levels, the G alpha2-null subunit of the G protein bypass the cell aggregation stage and forms fruiting bodies. The results suggest that these surface cell receptors are responsible for controlling cell-type differentiation and aggregation in the pathway.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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RNA polymerase II holoenzyme contains SWI/SNF regulators involved in chromatin remodeling
Article Abstract:
Biochemical studies of yeast showed that the transcription initiation apparatus, RNA polymerase II holoenzyme, consists of RNA polymerase II and the SRB (suppressor of RNA polymerase B) regulatory proteins SWI and SNF gene products. Analysis of the proteins identified four classes: SWI2/SNF2, SWI3, SNF5 and SNF11. These regulatory proteins provide the disruption of nucleosomal DNA that promotes activator and TATA-box binding to the nucleosomal DNA transcription initiation promoter sites.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
Article Abstract:
The indispensability of the RNA polymerase II carboxy-terminal domain (CTD) to the transcription initiation complex, and its interaction with a huge multisubunit complex consisting of a TATA-binding protein (TBP) was biochemically and genetically proved. SRB2, SRB4, SRB5 and SRB6 were established as genes concerned with the CTD function, by the characterization and isolation of extragenic suppressors of Saccharomyces cerevisiae RNA polymerase II CTD truncation mutations.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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