Signaling by transmembrane proteins shifts gears
Article Abstract:
The NMR structure of the HAMP domain is described, providing valuable insights into how the conformational change caused by a signal interacting with the external receptor domain is transduced to modulate the enzymatic activity of the kinase. It is proposed that the rotation of the HAMP domain would also move downstream elements by 26 degrees Celsius to transduce the signal and affect enzymatic activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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RTP family members induce functional expression of mammalian odorant receptors
Article Abstract:
A study demonstrates that the transmembrane proteins RTP1 and RTP2 promote functional cell surface expression of odorant receptors (Ors) expressed in HEK293T cells. Genes encoding these proteins are expressed specifically in olfactory neurons, the proteins interact with OR proteins and enhance the OR responses to odorants.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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How the ER stays in shape
Article Abstract:
Two membrane proteins, Rtn4A/NogoA and DP1/Yop1p, contribute to the generation of tubular morphology in the endoplasmic reticulum (ER). The overexpression of Rtn4A results in long processes in a cultured fibroblast-like cell line.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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