Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists
Article Abstract:
The BCL2 family of proteins plays a critical role in the regulation of programmed cell death. This family of proteins consists of both proapoptotic and antiapoptotic molecules, with all full members sharing homology in three or four conserved domains tagged BH1-4. The ratio of pro- (BAX, BAK and BOK) versus antiapoptotic (BCL2, BCLX(sub L), BCL-W, MCL1 and A1) members often determines how certain cells respond to proximal death and survival signals. The solution structure of proapoptotic BID is shown to shed light on the two mechanisms that govern proapoptotic activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Proapoptotic BID is an ATM effector in the DNA-damage response
Article Abstract:
The BH3-only BID protein partially localizes to the nucleus in healthy cells, is important for apoptosis induced by DNA damage, and is phosphorylated following induction of double-strand breaks in DNA. Results implicate BID as an ATM effector and raise the possibility that proapoptotic BID might also play a prosurvival role for S phase arrest.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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A role for proapoptotic BID in the DNA-damage response
Article Abstract:
BID has an unexpected role in the intra-S phase checkpoint downstream of DNA damage distinct from its proapoptotic function. The DNA-damage kinase ATM mediates this role through BID phosphorylation and these results establish a link between proapoptotic BID and the DNA-damage response.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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