Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord

Article Abstract:

Results show that Slit and Semaphorin proteins from midline and nonmidline tissues of the nervous system exhibit repellent activity. The repellent property prevents axons reentry into the gray matter but squeezes them into the surrounding fiber tracts.

Japan, Switzerland, California, Nervous system, Spinal cord

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Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons

Article Abstract:

Results indicate that calcineurin/NFAT is essential for axon growth, which is stimulated by growth factors such as neurotrophins and netrins. Data indicate that neutrotrophins and netrins stimulate nuclear localization of NFATc4 and activation of NFAT-mediated gene transcription in neurons, in a calcineurin-dependent manner.

Science & research, Growth, Developmental neurology, Company growth, Neurotrophins, Neurotropin

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Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

Article Abstract:

Plexins, a large family of vertebrate receptors for secreted, transmembrane, and GPI-anchored semaphorins, are discussed. The human plexin gene family has been shown to have four subfamilies with a minimum of nine members. The plexins trigger a novel signal transduction pathway that controls cell repulsion.

Italy, France, Statistical Data Included, Genetic aspects, Vertebrates, Cytochemistry, Neurons, Cell interaction, Cell interactions

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