Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans
Article Abstract:
Results demonstrate that in Aspergillus nidulans NIMA kinase localized to chromatin, phosphorylates histone H3. Data further show that NIMA kinase phosphorylates serine-10 of histone H3 in vitro.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila
Article Abstract:
Research has been conducted on the chromatin kinase JIL-1 functions. The analysis of these functions has been carried out via generation of the allelic series of the hypomorphic and null mutations and the results indicate that JIL-1 kinase activity is required for maintaining the structure of the open chromatin region facilitating gene transcriptions.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
Article Abstract:
Research demonstrates that Aurora-A, belonging to the Aurora family kinases, is essential for mitotic entry and its activation in late G2 phase of the cell cycle recruits cyclin B1-Cdk1 complex to centrosomes, where it commits cells to mitosis. Furthermore, the Aurora-A binding protein Ajuba induces autophosphorylation and activation of Aurora-A and in the absence of Ajuba mitotic entry is inhibited.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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