Stem cells: units of development, units of regeneration, and units in evolution
Article Abstract:
Evolution of development is discussed with emphasis on stem cells, particularly the hematopoietic ones (HSCs), the best-characterized of the stem cells. It is proposed that stem cell-based organogenesis and regeneration, stem cell mobility, and the coevolution of polymorphic histocompatibility that limits stem cells to self or close relatives are interrelated themes and are coselected in an evolutionary sense.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Genomic imprinting, mammalian evolution, and the mystery of egg-laying mammals
Article Abstract:
Mammalian evolution, genomic imprinting, and egg-laying mammals are discussed in this minireview. The mechanism of genomic imprinting, an unusal type of gene regulation in eutherians, can be better understood through greater understanding of the cis-regulatory regions. Differential expression of imprinted genes seems to regulate the asymmetry between parental contributions to the developing fetus.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Plasticity of adult stem cells
Article Abstract:
Adult mammalian stem cells can be capable of differentiating across tissue lineage boundaries, and as such may represent novel, accessible, and very versatile effectors of therapeutic tissue regeneration. The role of adult stem cells in tissue regeneration and studies suggesting lineage plasticity of adult stem cell populations is briefly reviewed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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