Streptomyces genomes: circular genetic maps from the linear chromosomes
Article Abstract:
Streptomyces genomes are discussed with information about circular genetic maps from the linear chromosomes. Only two bacteriophage are other known examples of the phenomenon, and they differ from the Streptomyces example. The circularity of Streptomyces genetic maps seems to come from a strong bias toward even numbers of crossovers in recombination. This creates misleading genetic linkages between markers on the opposite arms of the chromosome.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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Forty years of genetics with Streptomyces: from in vivo through in vitro to in silico
Article Abstract:
The genetics of Streptomyces and discoveries made over the last forty years are discussed in this review article which includes information about some of the researchers important in the great progress that has been made. Streptomyces has a chromosome that, at 8 Mb, is very, very large compared with plasmids and phages. A genome-sequencing project is underway and the complete sequence should be available by late 2000.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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Genetic instability associated with insertion of IS6100 into one end of the Streptomyces lividans chromosome
Article Abstract:
The Streptomyces lividans chromosome and its genetic instability, associated with insertion of IS6100 into one end of the chromosome, are discussed. Analysis of 548 recombinant strains of S. lividans having the insertions showed that six mutants had DNA amplifications. which differed in size but had IS6100 sequences.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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