Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(sup)val and valyl-tRNA synthetase

Article Abstract:

Crystal structure of the complex between valyl-tRNA synthetase, tRNA, and an analog of the valine intermediate reveals that the enzyme is capable of discriminating cognate L-valine from L-isoleucine and L-threonine by a "double sieve" mechanism, which is tRNA-dependent.

United States, Statistical Data Included, Proteins, Protein synthesis, Crystals, Crystal structure, Structure-activity relationships (Biochemistry), Amino acids, Ligases, Amino acid structure-activity relationships

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Alternative tertiary structure of tRNA for recognition by a posttranscriptional modification enzyme

Article Abstract:

Research has ben conducted on transfer RNA. The authors have investigated the crystal structure of this RNA bound with archaeosine tRNA-guanine transglycosylase.

Biological Product (except Diagnostic) Manufacturing, Drugs, Enzymes, Other Basic Organic Chemical Manufacturing, Guanine, Genetic aspects, Cell research, Cytological research, Structure

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Structural basis for transcription regulation by Alarmone ppGpp

Article Abstract:

An experimental evidence to show the importance of base-specific contacts between Guanosine-tetraphosphate (ppGpp) and specific cytosine residues during transcription and elongation are presented. The result reveals that base pairing of ppGpp with cytosines in the nontemplate DNA strand may be an essential component of transcription control by ppGpp.

Molecular structure, Guanosine triphosphatase, GTPases

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