Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking
Article Abstract:
Structural basis for interaction of FxFG nucleoporin repeats and importin-beta are discussed relative to nuclear trafficking. The crystal structure of a a complex of importin-beta residues 1-422 and five FxFG nucleoporin repeats form Nsp1p has been studied. RanGTP may release importin-beta from FxFG nucleoporins by generating a conformational change that alters the structure of the FxFG binding site.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Repression: targeting the heart of the matter
Article Abstract:
Transcriptional repression, which is essential to the precise control of gene expression, is discussed in this review article which focuses on repressors that affect formation of the initiation complex. Several functionally distinct general repressors of transcription are analyzed. Topics include the relationship between nucleosomes and general repressors, the Dr1/Drap1 complex, Mot1, the Srb10/Srb11 complex, the Not complexes, and multifunctional repressors.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Virus-bacterium interactions in water and sediment of West African inland aquatic systems. A comparison of methods for counting viruses in aquatic systems
- Abstracts: An evaluation of methods for the simultaneous detection of Cryptosporidium oocysts and Giardia cysts from water
- Abstracts: Distinct functions of the leucine-rich repeat transmembrane proteins Capricious and Tartan in the Drosophila tracheal morphogenesis
- Abstracts: Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding
- Abstracts: A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis