A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis
Article Abstract:
A chromodomain protein, Swi6, has been found to carry out imprinting functions in fission yeast during meiosis and mitosis. It is involved in imprinting the mat locus. Its transient overexpression changes the epigenetic implant at the mat2/3 region and it stays bound to the mat2/3 interval through the entire cell cycle and seems to be itself a component of the imprint. It converts the expressed state to the silenced one heritably.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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CENP-E as an essential component of the mitotic checkpoint in vitro
Article Abstract:
CENP-E, a microtubule-dependent motor protein that extends at least 100 nm from the surface of kinetochores, has been seen to be an essential component of the mitotic checkpoint in vitro. Xenopus egg extracts were studied to look into how CENP-E acts in establishing, maintaining and silencing the mitotic checkpoint. It was surprising that depletion of CENP-E brought failure to establish a checkpoint arrest when challenged with microtubule-depolymerizing agents.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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