Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
Article Abstract:
Research has been conducted on the DNA double-strand break repair. The biochemical and structural characterization of the ATP-bound and ATP-free catalytic domain from Pyrococcus furiosus has been carried out.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
Article Abstract:
Research has been conducted on the Mre11/ Rad50 complex in DNA double-strand break repair. The functions of this complex have been investigated and the crystal structure analysis of the complex indicates that Pyrococcus furiosis Mre11 has a protein phosphatase-like binding domain capped by the controlling active site access domain.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA
Article Abstract:
The crystal structures of a dsDNA-translocating SWI2/SNF2 ATPase core from Sulfolobus solfataricus reveal two helical SWI2/SNF2 specific subdomains, fused to a Dexx box helicase-related ATPase core. The torque in remodeling processes is generated by an ATP-driven screw motion of DNA along the active site cell and redefines SWI2/SNF2 functional motifs and uncovers unexpected structural correlation of mutations in Cockayne and X-linked mental retardation syndromes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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