Structural insights into the mechanism of intramolecular proteolysis
Article Abstract:
The mechanism of intramolecular proteolysis is discussed based on new insights into structure. The 1.9-angstrom crystal structures of glycosylasparaginase (GA) precursors able to autoproteolyze through an N --> O acyl shift is presented. Various proteins, among them GA, have been found to activate functions by self-catalyzed peptide bond rearrangements from single-chain precursors. GA is the prototype of these proteins.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Alterations in DNA methylation may play a variety of roles in carcinogenesis
Article Abstract:
Changes in methylation of DNA play an important role in carcinogenesis. Change in normal gene expression is related to increases or decreases in DNA methylation. Increased gene expression is related to hypomethylation of DNA. It may promote the development of tumor tissues by clonal expression of tumor progenitor cells. Hypermethylation of specific regions of DNA may inhibit the expression of tumor suppressor genes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Change of plasmid DNA structure, hypermethylation, and Lon-proteolysis as steps in a replicative cascade
Article Abstract:
Research shows that plasmid DNA contains fully methylated DNA of lowered helical density, which represents a precursor of replication. Furthermore, Lon-protease removes the proteins that lower the helical density during plasmid DNA replicative process.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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- Abstracts: Structural basis for the excision repair of alkylation-damaged DNA. Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: structural basis for damaged DNA recognition
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