Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway
Article Abstract:
A study illustrates that protein translocation into the endoplasmic reticulum (ER) lumen is not a constitutive or deterministic process but instead could be regulated in response to changes in cellular conditions. It is found that during acute ER stress, translocation of secretory and membrane proteins is rapidly and transiently attenuated in a signal sequence-selective manner and their cotranslational rerouting to the cytosol for degradation reduces the burden of misfolded substrates entering the ER and represents a pathway for pre-emptive quality control (pQC).
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload
Article Abstract:
A study was presented to report that P58[super IPK]/DNAJC3, an unfolded protein response-responsive gene previously implicated in translational control, encodes a cytosolic cochaperone that associates with the ER protein translocation channel Sec61. It is found that P58[super IPK] plays a mediator of cotranslocational ER protein degradation, and this process likely contributes to ER homeostasis in stressed cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
Article Abstract:
The transcription factor C/EBP homologous protein (CHOP) is activated by endoplasmic reticulum (ER) stress, and CHOP deletion protects against its lethal consequences. It is observed that CHOP directly activates GADD34, which promotes ER client protein biosynthesis by dephosphorylating phospho-Ser 51 of the alpha-subunit of translation initiation factor 2 (elF2(alpha)) in stressed cells.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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