Switching the model: a concerted mechanism for GTPases in protein targeting

Article Abstract:

Guanosine triphosphatases (GTPases) regulate protein targeting via a signal recognition particle (SRP) and SRP receptors by binding and hydrolyzing guanosine triphosphate (GTP) via a molecular switch mechanism. The empty state of the GTPase was characterized as the transient intermediate in the exchange of guanosine diphosphate and GTP via a slow hydrolyzing process. Furthermore, the concerted switch model for GTPase-mediated regulation of protein targeting involved high fidelity interactions.

Enzymes, Proteins, Enzyme structure-activity relationships, Guanosine triphosphatase

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Rab conversion as a mechanism of progression from early to late endosomes

Article Abstract:

Novel image analysis algorithms is combined with fast live-cell imaging to visualize and quantify the dynamics of membrane bound Rab5 and Rab7 during the transport of Low Density Lipoprotein (LDL) from early to late endosomes. Results reveal that the level of Rab5 dynamically fluctuates on individual early endosomes, linked by fusion and fission events into a network in time.

Science & research, Low density lipoproteins, Cell research, Cytological research

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Transport across membranes: a question of navigation

Article Abstract:

This review reports on the proceedings of a conference on the macromolecular transport across cellular membranes. Research shows that protein translocation machineries of membrane origin share many features and that translocation across membranes is not unique to any individual system.

Canada, Physiological aspects, Biological transport, Macromolecules, Cell organelles, Organelles

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