PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

Article Abstract:

PERP is a novel member of the PMP-22/gas3 family and an apoptosis-associated target of p53. A differential screen has been carried out. IN it G(sub.1)-arrested MEF TNA populations were taken out of apoptotic EqA MEF RNA populations to select against genes induced by p53 in nonapoptotic cells. Using the novel subtractive cloning approach the new p53 target gene was found. It is a candidate effector in the p53-dependent apoptotic pathway.

Cytogenetics

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Targeted disruption of the three Rb-related genes leads to loss of G(sub.1) control and immortalization

Article Abstract:

Targeted disruption of the three Rb-related genes has been found to lead to loss of G(sub.1) control and immortalization. Triple knock-out mouse embryonic fibroblasts have a shorter cell cycle than wild-type, single-, or double-knock-out control cells. The Rb family is essential in the control of the G(sub1) /S transition, place the three Rb family members downstream of multiple cell cycle control pathways, and further the link between loss of cell cycle control tumorigenesis. The RB tumor suppressor gene is implicated in a considerable variety of human tumors.

Mice, mutant strains, Mutant mice, Mammals

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

Article Abstract:

INK4a/ARF mutations have been found to speed lymphomagenesis and promote chemoresistance by disabling p53. The impact of INK4a/ARF mutations on tumor development and therapy have been studied through use of E-mu-myc transgenic mice. The mice constituitively express c-Myc in the B-cell liage and develop B-cell lymphoma with associated leukemia. There are several reasons for using the mouse model. Human systems are much more difficult to work with.

Health aspects, Usage, Gene mutations, Gene mutation, Biological models, Lymphomas, Carcinogenesis, Genetically modified mice, Oncogenes

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