The Cdk-activating kinase (CAK) from budding yeast
Article Abstract:
The Cdk-activating kinase (CAK) was purified and cloned from budding yeast. Cak1p is unlike the CAKs from other organisms in that it is active as a monomer, is not a component of the basal transcription factor TFIIH and has full activity when expressed in E. coli. A temperature-sensitive mutation in CAK1 provides a G2 delay and low Cdc28p protein kinase activity. It shows genetic interactions with altered expression of the gene for the major mitotic cyclin CLB2. The derived data showed that the predominant CAK in vertebrate cell extracts, p40 super MO15-cyclin H-MAT1, may not function as a physiological CAK.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Recycling the cell cycle: cyclins revisited
Article Abstract:
The advances in the cell cycle in the 21 years since cyclin was discovered are discussed. The probable evolution of a cyclin /Cdk-based engine to assume control of the cell cycle from the other, older protein kinases is described.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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The 1.7 Angstrom crystal strucure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation
Article Abstract:
Researchers discuss several residues of the checkpoint kinase Chk1 that are important for binding substrate. This enzyme is involved in stopping the cell cycle so that damaged DNA can be repaired.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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