The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis
Article Abstract:
Pkn protein kinase in Drosophila is a Rho/Rac effector target necessary for dorsal closure in embryogenesis. The PKN family of PKC-related protein kinases have the major Rho GTPase-associated protein kinase actions found in mammalian tissues, the biological functions of which are not known. It seems distinct but coordinated Rho- and Rac-mediated signaling pathways regulate the cell shape changes needed for dorsal closure. Also it seems Pkn offers a GTPase effector function for cell shape changes in vivo. That acts with a Rac-JNK transcriptional pathway in the morphogenesis of the Drosophila embryo.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes
Article Abstract:
Myoblast city (mbc) may specifically regulate upstream Rac activity which in turn mediates several morphological processes in Drosophila embryonic formation. Eleven alleles of myoblast city were isolated in mutant embryos, which showed defects in dorsal closure, neural development, and myogenesis. Rac and Cdc42GTPases are regulated by several substances, and the results here suggest mbc serves as one regulator.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Activiation of Rac1 by a Crk SH3-binding protein, DOCK180
Article Abstract:
The protein DOCK180 may be a novel activator of Rac1 and a significant factor in integrin signaling. Research has shown this protein is involved in Rac1 signaling cascades. Overexpression of DOCK180 increased the GTP-bound Rac1 in 293T cells, and bound to Rac1 but not to RhoA or Cdc42Hs.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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