The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development

Article Abstract:

The Drosophila p38 MAPK pathway is necessary for egg asymmetric development in oogenesis. The role of p38 MAPK signaling in unchallenged conditions is not well understood. Mutations in a Drosophila p38 MAPKK gene homolog, licorne (lic) has been isolated. It was shown that in oogenesis lic is necessary in the germ line for the asymmetric development of the egg to take place as it should. Loss of lic function in the germ line brings reduced EGF receptor activity in dorsal follicle cells and ventralization of the egg shell. Results of the study constitute the first genetic demonstration of an essential development function of a p38 pathway.

United Kingdom, United States, Japan, France, Cellular signal transduction, Protein kinases, Mitogens

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Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation

Article Abstract:

In Drosophila the zinc-finger transcription factor, CF2, is active in encoding of a required membrane-bound component of the dorsalizing pathway. Expression of CF2 is stopped by the activated EGF receptor (Egfr). That CF2 is the target of down-regulation by the MAPK kinase cascade has been shown. D/V patterning involves a 2-step signaling process. The first Egfr signal represses CF2 and the later Egfr + rhomboid gene (Rho) signal. The signal determines dorsal cell fates. The CF2 down-regulation takes place at the post-translational level via a mechanism that involves coupled cytoplasmic retention/degradation.

Gene expression, Post-translational modification

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okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis

Article Abstract:

Among female sterile loci responsible for defects in oocyte and egg morphology are okra (okr), spindle-B (spnB), and spindle-D (spnD). okr and spnB code for parts of the RAD52 DNA repair path. They affect meiosis and patterning in Drosophila oogenesis. Like its yeast homolog, okr is necessary in both mitotic and meiotic cells, but spnB and spnD seem to be necessary in meiosis only.

Meiosis

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