Interactions with Costal2 and Suppressor of Fused regulate nuclear translocation and activity of Cubitus interruptus

Article Abstract:

The Hedgehog (Hh) family of secreted proteins prevents formation of a truncated repressor form of Cubitus interruptus (Ci) in Drosophila. Evidence that Costal2 (Cos2) and Suppressor of Fused (Su(fu)) inhibits Ci by tethering it in the cytoplasm has been found A 125-amino acid domain in the C-terminal part of Ci that mediates response to Cos2 inhibition has been identified. Cos2 binds Ci and prevents its nuclear import. It also inhibits its activity via the domain mentioned. Evidence that (Su(fu)) regulates Ci through two mechanisms is presented. Other findings are discussed.

Developmental biology, Genetic regulation, Cell nuclei, Cell nucleus

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The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

Article Abstract:

Research has been conducted on tumor suppressor gene which encodes mammalian Ste20 kinase family members' Drosophila homolog. The authors report that the loss-of-function mutations in this gene leads to overgrown tissues containing more normal size cells.

Science & research, Analysis, Protein kinases, Tumor suppressor genes, Cell proliferation, Genetic research, Apoptosis, Tumour suppressor genes

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Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

Article Abstract:

Protein kinase A and its antagonism of Hedgehog signaling, regulating the activator and repressor forms of Cubitus interruptus (Ci), are discussed. In vivo evidence shows that phosphorylation of Ci by PKA targets Ci from Slimb-mediated proteolysis and inhibits activity of the full-length activator form of Ci independent of its processing.

Statistical Data Included, Cellular signal transduction, Developmental genetics, Proteolysis, Extremities (Anatomy)

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